Eric Garcetti, who is in Glasgow as part of the international delegation of mayors from C40 Cities at COP26, tested positive for COVID-19 earlier on Wednesday.
"He is feeling good and isolating in his hotel room. He is fully vaccinated," Garcetti's official Twitter account said.
Earlier during the COP26 conference, Garcetti was actively taking part in public events and being photographed with other participants, including American businessman and president of the C40 Cities Climate Leadership Group board, Michael Bloomberg, and London mayor Sadiq Khan.
In October, it was revealed that Khan is set to succeed Garcetti as chairman of C40 Cities.