Chinese Foreign Ministry spokesperson Hua Chunying made the comments in response to a tweet from the US Department of State that claimed Beijing's actions "upend global institutions to serve its own ambitions."
Hua said on Monday that "telling a lie a thousand times does not make it true."
"In fact, it is the US that has been pulling out of multilateral treaties, breaking promises, and playing at will with sanctions and threats to other parties," Hua said.
The outgoing administration of US President Donald Trump pulled the US out of more than 10 international treaties, covering areas such as climate change, arms control, and non-proliferation, she said.
She also criticized the US withdrawal from the World Health Organization (WHO) at a critical moment when the international community is united in fighting the coronavirus pandemic.